Abstract
Conclusion
The fraction containing the somatic antigen-complex of the typhoid-bacillus is highly toxic. The macroscopic changes observed are those attributed to the so-called endotoxin. 5 The histopathological changes observed indicate that the effect of the toxin is primarily on the blood vessels, damage to which results in degenerative changes in the tissues supplied. A monocytic response is not a component of the tissue-response to the toxin.
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