Abstract
Conclusion
The growth of some common bacteria in “normal non-reactive sera” causes them to produce a pyrogenic symptom-complex when injected intravenously into dogs. This symptom-complex consists of fever, leucopenia, and in severe cases chills and gastro-intestinal disturbances, and is indistinguishable from that produced by therapeutic reactive sera, reactive acacia, reactive inulin,. or reactive infusion-fluids.
On the basis of these experiments it is suggested that the chill- and fever-producing substance in sera may be pyrogen, caused either by direct bacterial growth or by pyrogen already present in chemicals used in the purification and concentration of therapeutic sera.
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