Abstract
Summary
Dead Brucella organisms and Brucella proteins injected intradermally in normal guinea pigs provoke an immediate but mild and evanescent inflammatory reaction with eosinophils and neutrophils, and without edema. In sensitized animals the local reaction is more violent, mainly neutrophilic and accompanied by marked edema. It rises to its height the 3rd day after injection and then rapidly regresses. Qualitatively, the changes provoked by Brucella protein are similar to those induced by dead bacilli.
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