Abstract
Summary
Three samples of acetone dried whale anterior pituitary and 40% alcohol extracts thereof were assayed in normal and hypo-physectomized female rats. In the first sample, only the presence of FSH could be demonstrated, no interstitial cell stimulating, luteinizing, antagonistic or thyrotropic activity was observed at the dose levels employed. Samples II and III showed the presence of both FSH and ICSH, concurrently with luteinizing, antagonistic and thyrotropic activity. Sample II was also tested for adrenotropic activity and it was found that this factor was present. The gonado-tropic activity of 40% alcohol extracts of samples II and III is of the same order as that of similar preparations obtained from sheep and pig pituitary. The absence or presence of the multiple properties of the LH (ICSH) factor agrees with our assumption that they are due to one principle only.
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