Abstract
Summary
There is a high degree of correlation between the malignancy of chemically induced tumors, as measured by growth rate and mitotic index, and shortness of the latent period before appearance of palpable tumors. This relation holds true in the various responses of different strains of mice to the same agent, and in responses to different agents and modes of administration.
It is suggested that the growth rate of a tumor in the microscopic stage is important and may be the main factor determining the latent period in carcinogenesis.
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