Abstract
Conclusions
Bradycardia which was sometimes preceded by tachycardia developed in dogs poisoned with ethylene glycol. The cardiac arrhythmia of both immature and mature dogs were both regular and irregular in character. The regular alteration of rhythm was caused by an exaggerated sinus arrhythmia. The irregularity of cardiac rhythm of pups was caused by sino-auricular block, whereas, in adult dogs, it was caused not only by sino-auricular block but also by nodal and ventricular extra-systoles. A partial A-V block developed in only one of the 4 adult dogs and in this instance it did not occur until 2 hours before death. x/trio-ventricular block, therefore, appeared to be an exception rather than a rule in ethylene glycol poisoning. The deep S waves and the displacement and curvature of the S-T segment combined with a diphasic T wave were constant findings in the electrocardiograms of adult dogs after the developmeent of toxic symptoms of ethylene glycol poisoning. Similar S-T changes occurred in pups but much less extensively. The abnormal S-T complex (deep S wave, low take-off and convex curvature of S-T segment followed by a diphasic T wave) therefore appeared to be a characteristic alteration of the electrocardiograms of dogs poisoned with ethylene glycol. The electrocardiograms of dogs poisoned with “Prestone” were identical with those poisoned with c.p. ethylene glycol.
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