Abstract
Summary
Sulfanilamide by subcutaneous and intraabdominal injection and sulfapyridine by intraabdominal injection in dose of 0.160 g per kilo slightly prolonged the lives of some mice when given 2 hours after intraabdominal inoculation with B. coli in a dose fatal in 24 to 48 hours, followed by a second dose 4 hours later and thereafter twice daily (10 A.M. and 3 P.M.) for 5 days. All of the treated mice succumbed with positive heart-blood cultures and the unfavorable results are believed to be due to the fact that the strain of B. coli employed was one unusually resistant to the bacteriostatic and bactericidal effects of sulfanilamide as indicated by the results of in vitro tests. All treatment-controls lived for 12 days, when the experiments were terminated.
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