Sulfanilamide and Sulfapyridine in Treatment of Experimental B. Friedländer (Klebsiella pneumoniae) Infections of Mice

Abstract

Summary

Sulfanilamide by subcutaneous injection in dose of 0.160 g per kilo slightly prolonged the lives of 3 out of 16 mice when given immediately, 6 hours later and thereafter twice daily for 5 days after intraabdominal inoculation with B. friedländer in a dose fatal in 24 to 72 hours. When the compound in the same dose was given by intraabdominal injection in the same manner to 16 mice, 2 survived 12 days when the experiment was terminated, while the lives of 6 were prolonged for 3 to 6 days beyond the untreated controls. Of the total of 32 treated mice, 2 survived and the lives of 9 were prolonged, whereas all of 8 untreated controls succumbed in 1 to 3 days after inoculation.

Sulfapyridine was somewhat more effective. Of 16 mice given 0.160 g by intraabdominal injection immediately after inoculation, 6 hours later and thereafter twice daily for 5 days, 4 survived while the lives of 6 were prolonged 1 to 5 days beyond the survival of 4 untreated controls which succumbed in 24 to 72 hours after inoculation. All treated and untreated mice succumbing gave positive heart-blood cultures. All drug controls given both sulfanilamide and sulfapyridine by subcutaneous and intraabdominal injection survived the period of 12 days, when the experiments were terminated.