Some Effects of Testosterone on Sexual Differentiation of Female Albino Mice

Abstract

Summary

Fifty-six genetic female mice have been examined subsequent to the prenatal administration of testosterone; 18 subsequent to both prenatal and postnatal treatment; and 20 subsequent to postnatal treatment alone. When testosterone is present in the pregnant mother, at a critical period, Wolffian duct derivatives persist and vaginal differentiation is inhibited. With sufficient testosterone treatment the clitoris is modified into a veritable penis and the utero-vaginal canal opens into the prostatic urethra.