Abstract
Summary
1. Calcium creosotate administered either in single doses of 0.5 to 2.0 g or in amounts and at intervals approximating its therapeutic application (0.5 g every 2 hours) did not produce bac-teriostatic urine in normal human subjects. 2. Evidence was obtained that practically all of orally administered calcium creosotate which is excreted in rabbit urine is present in conjugated form. 3. Data are presented to show that after hydrolysis of the conjugates a portion of orally administered creosote could be recovered in rabbit urine. This indicates that the methoxy compounds are not more readily destroyed in the body than the other phenols of the mixture.
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