Effect of Adrenal Insufficiency on Distribution of Chlorides Between Plasma and Erythrocytes

Abstract

Conclusions

Experiments on adrenalectomized rats indicate that the red cell chloride concentration decreases much more markedly during adrenal insufficiency than does the plasma or whole blood chloride content. In cases of slight hypochloremia caused by moderate adrenal insufficiency, the direct or indirect determination of the red cell chloride concentration or of the index Cl_c: Cl_Pl is a more sensitive index of a change in chloride metabolism than the more commonly determined plasma or whole blood chloride concentration.