Quantitative Prothrombin and Hippuric Acid Determinations as Sensitive Reflectors of Liver Damage in Humans. ∗

Abstract

Conclusion

In the human subjects here studied, without biliary obstruction of biliary fistulae, the quantitative levels of plasma prothrombin and the amounts of hippuric acid excreted following the ingestion of a known quantity of sodium benzoate would seem to have reflected most sensitively and consistently the degree of liver damage existing. There was no such suggestive correlation or relationship observed between these tests and the plasma fibrinogen levels, the bromsulphalein dye clearance or galactose utilization, either singly or collectively, when all were studied in the same patient.