Abstract
Conclusions
From the urine of normal individuals there can be extracted a substance which when given intravenously inhibits gastric secretion stimulated by histamine. This gastric secretory depressant is inactivated by heating for 4 hours at 99°C. When given subcutaneously, the daily amount found effective for protection against the Mann-Williamson ulcer is too small a dosage to reduce gastric secretion. 2 Extracts of urine from ulcer patients do not protect against the experimental ulcer but do reduce gastric secretion. From this and other data it would seem probable that the apparent beneficial effect on Mann-Williamson ulcers previously reported may be due to some factor in the urine extract other than the one which inhibits gastric secretion. We do not as yet know the nature of the substances nor what organ or mechanism of the body is responsible for their elaboration.
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