Abstract
Summary
When treatment was begun 4 hours after the time of inoculation with the infecting dose, both sulfanilamide and sulfa-pyridine were partly effective in protecting rats against Type III pneumococcal pneumonia. There was no significant difference under the conditions stated between the effects of the 2 drugs in preserving life but the survival time of animals dying of infection was on the average 2 days longer in the group treated with sulfapyridine. Prolongation of the period of treatment from 6 to 10 days did not appear to reduce the mortality but the number of animals used was insufficient to permit definite conclusions on this point. The complications of empyema and purulent pericarditis were less frequent in animals treated with sulfapyridine even though the period of survival was longer in the treated animals.
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