Effect of Neoprontosil on Bacterial Toxins

Abstract

Summary

Neoprontosil was administered orally, subcutaneously, intraäbdominally, or intramuscularly to a total of 740 mice which had received lethal doses of 5 bacterial toxins by intraäbdominal injection. Oral administration of the drug prevented death in 87.7% of 440 mice given staphylococcal toxin, 77.5% of 80 mice given streptococcal toxin, 84% of 100 mice given the toxin of Clostridium welchii, and 86.7% of 60 mice given the toxin of Clostridium botulinum. On the other hand, only 5% of 60 mice injected with gonococcal “toxin” survived. In all instances, the compound was ineffective when administered parenterally.