Abstract
Summary
Clamping the aorta above the orifices of the renal artery in dogs is followed by elevation of the diastolic level of arterial pressure in the hind legs as well as in the carotid arteries. Constriction of the peripheral arterioles is, therefore, a general phenomenon, just as when it follows partial clamping of the renal arteries. The hypertension which develops in coarctation of the aorta in man is on this evidence analogous to that which accompanies constriction of the renal arteries. The evidence suggests strongly that interference with the hemodynamics of the renal circulation leads to hypertension in man as well as in animals.
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