Abstract
Summary
1. A procedure is described for the determination of the free volatile acids of tissues. 2. Normal tissues of the dog, with the exception of brain, contain only traces, from 0 to 0.25 mM or cc N, of free volatile acidity per kg. This constitutes from 1 to 3% of the total volatile acids which can be obtained by hydrolysis with 2 N H2SO4. About 10%, from 1.5 to 2.0 mM, of all of the volatile acids of the brain are present either as free acid or in some form which is readily hydrolized. 3. The metabolism of ethyl alcohol in the dog does not result in an increase of the free volatile acids of the blood and tissues.
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