Abstract
Summary
The recent chrome acid-fast culture produces lesions in the rabbit that grossly and microscopically resemble those seen in human leprosy. Here, the lesion is definitely progressive over a period of 4 or more months. During this period it is noteworthy that the exciting microörganism steadily increases in number. The “foamy” cells are crowded with dense colony-like masses of the specific bacillus. The chromogenic acid-fast bacillus was recovered in culture from the lesions of the animals 4 months following the last injection. The isolation of the bacillus used in the experiment was more difficult from the lesions that were 4 months old than from the earlier lesions. Visible growth occurred only after 4 weeks' incubation. In the control animals no gross or microscopic lesions were noted 4 months after the last inoculation. The cultures inoculated with material from these animals remained sterile after 4 weeks' incubation.
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