Abstract
Several observers have determined the effects on the blood pressure of injecting multiple emboli into the renal arteries. Senator 1 injected liquid paraffin into the renal arteries of cats and no elevation of blood pressure occurred. Cash 2 injected insoluble Berlin blue into the renal arteries of dogs. The blood pressure did not become elevated. Similarly, no rise in the blood pressure of dogs was detected by Apfelbach and Jensen 3 following the injection of particles of charcoal. On the other hand, Maegraith and McLean 4 reported recently the results of experiments in which arterial hypertension was produced in rabbits by the injection of a suspension of Kiesel-guhr white into one renal artery. Even more interesting is their finding that the blood pressure returned to normal following the excision of the renal nerves. Renal denervation, or in fact total sympathectomy, 5 does not abolish in dogs the hypertension that is associated with partial constriction of the renal arteries by Goldblatt clamps. Because of this difference, the effect on the blood pressure of dogs of injecting Kieselguhr into the renal arteries has been determined.
A total of 14 dogs were used. Eight died after intervals of one to 21 days following the introduction into the right renal artery of from 0.5 to 20 cc of 1% suspension of Kieselguhr white. None of these animals developed a rise in blood pressure as determined by needle puncture of the femoral artery. Varying degrees of destruction of the kidney substance were observed. Complete liquefaction followed the introduction of the large doses. The right kidneys of 6 dogs surviving for 20 to 35 days the injection of the right renal arteries with from 1.0 to 6.5 cc of Kieselguhr suspension were explored and changes varying from complete necrosis to a small hard kidney were found.
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