Clinical Experience with Globin Insulin

Abstract

A clinical trial of globin insulin 1 was made on approximately 25 patients suffering from diabetes of varying degrees of intensity. The preparation was given in a single dose, usually 30–45 minutes before breakfast. Whenever possible, its action was compared with standard and protamine zinc insulin. The sugar in the urine was usually determined in 2-hour periods. Four finger blood sugars taken before breakfast, lunch, dinner and 10 P.M. respectively were also recorded at frequent intervals. The maximum single dose was 145 units. Skin reactions were never encountered. We were using a water-clear solution. When hypoglycemic reactions occurred, the time was usually in the late afternoon, whereas protamine zinc insulin shocks usually occur in the early morning hours. It was found that in practically every case a single dose of globin insulin would regulate the moderately severe and mild cases. In several severe cases, uncontrollable with protamine insulin, fair regulation was obtained with the globin compound. An illustrative table is included.

Thanks are due Drs. Edgar Stillman, Bertram J. Sanger, Henry E. Marks and Rudolph Scharf for their coöperation.