Abstract
Conclusions
The permeability and the chemotactic factors found in inflammatory exudates exist as well in the crystalline nitrogenous substance, leukotaxine, recovered from such exudates by chemical fractionation. There is no evidence to support the contention that the permeability factor is histamine. Extraction by the method of Barsoum and Gaddum has failed to reveal the presence of histamine in leukotaxine. Furthermore, alkaline hydrolysis of leukotaxine does not dissociate the permeability from the chemotactic factor. The foregoing observations add further support to the view that leukotaxine is the substance liberated from injured tissue which is primarily responsible for the basic sequences of the inflammatory reaction, namely, the initial increase in capillary permeability and the prompt migration of polymorphonuclear leukocytes.
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