Abstract
Summary
The concentration of M & B 693 has been determined in the body fluids of the rabbit, dog, and human, following its administration in varying doses. Blood analyses show the appearance of free M & B 693 directly after ingestion; no acetylated form is detectable until later. The percent acetylated is roughly constant for an individual and varies widely around 50% among human subjects. No free drug can be detected in general 24 hours after the last dose and essentially all the acetylated form is eliminated in 48 hours. Urine analyses confirm these findings.
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