Abstract
Summary
Heparin added to whole blood in vitro or administered by vein prolonged the coagulation time of whole blood and plasma. The coagulation time was prolonged and maintained by single large dose of heparin followed by a smaller continuous dose. The mechanism appeared to be independent of the presence and type of disease. Heparin produces agglutination and disintegration leucocytes and bone marrow pulp in vitro.
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