Abstract
Summary
1. Filtrates of Cl. histolyticum grown on various protein-rich media possess a high fibrinolytic potency, whether sulphydryl activator be present or not. 2. This fibrinolytic potency is greatly depressed in the presence of dog serum. 3. It is probable that the use of filtrates of Cl. histolyticum as a fibrinolytic agent in dissolving fibrin deposits in vivo would not be feasible due to the antienzymatic properties of blood serum.
I am grateful to Dr. L. N. Katz, to Dr. K. Howell, and to Dr. I. Kaplan for helpful suggestions and advice.
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