Effect of Prolonged Theelin Injections on Transplantable Mammary Adenofibroma.∗

Abstract

Conclusions

Bi-weekly injections of 50 i.u. of aqueous theelin over a period of 165 to 368 days in male white rats implanted with adenofibroma did not prevent these tumors from undergoing fibromatous changes except in one tumor growing in a 160-day-old theelin-treated animal, which underwent massive glandular hyperplasia. A reduction in body weight after large doses of theelin, as reported previously, did not occur in either age group with smaller amounts given over longer periods, nor did the amount of theelin affect the daily growth rate of adenofibroma, Strain 1-a.