Relationship Between Inactivated Prolan and Antiprolan

Abstract

Conclusion

Boiled prolan is still able to initiate antiprolan formation for one hour's boiling leaves 0.3-1% active substance. These minute amounts of prolan are sufficient for the formation of antiprolan. After complete inactivation through heat prolan is neither able to produce antiprolan in vivo nor paralyze antiprolan in vitro. Since prolan consists of an active prosthetic group and an inactive carrier (Euler and Zondek '34) we conclude: The capacity of prolan to initiate the formation of antiprolan through protracted treatment and the capacity of paralyzing antiprolan in vitro is immanent in the active prosthetic group and not in the carrier substance which is hormonally ineffective.