Abstract
Summary
(1) Narcotics belonging to various chemical groups inhibit the histamine contraction of plain musculature (intestinal strips of guinea pigs). (2) This inhibiting action of the narcotics can be enhanced by (a) substitution of aliphatic radicals with increasing C-atoms; (b) substitution of a phenyl group; and (c) halogenation. (3) The described inhibitory action is probably due to the relaxing effect of narcotics on plain musculature.
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