Abstract
Summary
Chinese hamsters infected with kala-azar seemed to have a lower tolerance for neostibosan than normal. hamsters, but the difference was not statistically significant. Five to 7 g of neostibosan per kilo body-weight constituted a course of treatment. The range of the effective dose was from 200 to 500 mg per kilo. The mortality rate during treatment was 31.6%. The apparent cure-rate in hamsters surviving the treatment was 100%, but the actual cure-rate was only 50%. An inoculation test is necessary to prove actual cure. Nine out of 14 apparently cured hamsters were refractory to a second inoculation with Leishmania donovani. Spontaneous recovery from and relapse of kala-azar were seen in Chinese hamsters.
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