Neostibosan and Experimental Kala-Azar in Chinese Hamsters. I. Normal Hamsters

Abstract

Summary and Conclusions

1. In normal Chinese hamsters it was found that the maximum non-lethal dose of neostibosan is 1.0 g per kilo body weight; the maximum tolerated dose, 3.0 g per kilo body weight; and the universal lethal dose, 4.0 g per kilo body weight. 2. The sex and body weight of hamsters played no significant rôle. The maximum non-lethal dose was found universal to animals weighing from 11 to 40 g. 3. There was no increase of tolerance after repeated injections of gradually increasing doses of neostibosan. A cumulative effect was clearly shown. A probable therapeutic dose was found to be about 0.4 g per kilo body weight. 4. After an animal had been poisoned by a large dose of neostibosan, the repetition of the same or greater amount even after an interval as long as 2 months usually resulted in death.