Abstract
Conclusion
The presence of the hypophysis is necessary to adrenal hypertrophy in animals hearing Walker So. 256 tumor. This finding suggests that the pituitary may be essential to any adrenal cortex hypertrophy. Either certain toxins or metabolic processes sensitize the adrenal tissues to the pituitary adrenotropic hormone or they act directly on the hypophysis itself to cause an increased output of this substance. Work is now in progress to determine which process is involved.
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