Abstract
Summary
Although they do not offer direct proof our experiments support the view that the reduction in liver fat caused by the pancreas extract which Dragstedt has described as lipocaic is due to the sum of the lipotropic effects of the choline and protein which it contains. The influence of the pancreas extract upon the fat content of the livers of rats on a low protein and low choline but high fat diet is greater than that of a similar amount of protein in other forms. The ketosis which results when rats with such fatty livers are fasting is reduced about equally by the pancreas extract and an equivalent amount of casein. Althought both the choline and the protein contained in the pancreas extract affect the fat content of the liver, choline is without antiketogenic activity under the conditions studied here.
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