Activity of Insulin in Diabetic Hyperglycemic Animals

Abstract

Conclusions

1. In 8 diabetic dogs there was a definite decrease in the hyperglycemia during the hourly injection of amounts of insulin less than that required for the maintenance of a constant blood sugar level within the normal physiological range. Hourly amounts of insulin which would have allowed the blood sugar to rise when given at a level of 100 mg. % caused the blood sugar to fall when given at hyperglycemic levels. 2. In untreated diabetes mellitus, factors other than the hyperglycemia must be responsible for the severity of the condition, as the high blood sugar per se does not interfere with the ordinary action of insulin.