Failure of Nicotinic and Yeast Nucleic Acids in “Filtrate Factor” Deficiency in Rats. ∗

Abstract

Summary

Female rats received a diet in which all the known factors of the vitamin B₂ complex were supplied except that found in a multiply adsorbed liver filtrate. They failed to show a growth response on the addition of nicotinic acid, yeast nucleic acid, or a combination of the two to their ration. Liver filtrate, on the other hand, produced an immediate and marked stimulus to growth.