Abstract
Summary
1. In numerous healthy individuals and normal experimental animals hypoglycemia entails hyperglycemia in the post-absorptive state, irrespective of the experimental conditions which initiated the hypoglycemia. The phenomenon is interpreted as the result of a delay in the adjustment between the reaction velocities of glycogen breakdown and glycogen formation in the liver. 2. In the diabetic the same physiologic process takes place on a greatly magnified scale. Hypoglycemias, caused by overdoses of insulin, entail in the diabetic patient excessive degrees of hyperglycemia and glycosuria. Recurrence of this sequel over considerable periods of time progressively increases the instability of the patient and aggravates the disease.
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