Effect of Theelin on Transplantable Mammary Rat Adenofibroma. ∗

Abstract

Conclusions

In spite of long-continued injections of theelin, a rapidly growing mammary adenofibroma of the white rat transplanted into 32 rats lost a large part of its adenomatous content. No unusual growth behavior attributable to the injection of an estrogenic hormone could be demonstrated in the tumor tissue either grossly or microscopically. Theelin decreases body weight, but the size of the dose, in the limits given, is not significant. In other words, the loss in weight is not significantly greater when administering 200 i.u. than it is when administering 100 i.u. However, theelin has no significant effect on the mean daily changes in tumor weight.