Abstract
Summary
The enzyme carboxylase which plays an important ru1e in carbohydrate metabolism of plants was discovered by Neuberg in 1911. Only 21 years later was it shown by Auhagen that the activity of this enzyme depends on the presence of a specific coenzyme. At the same time Auhagen found that for full activity Mg ions are necessary. This was also known to be the case with zymase. Recently Lohmann and Schuster have shown that cocarboxylase is the pyrophosphoric acid ester of thiamin (vitamin B, pyrophosphate) and that manganese ions are better activators than magnesium ions. Copper, iron, bismuth, and cadmium salts, as well as sodium fluoride inhibit the activity of the enzyme carboxylase.
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