Abstract
Conclusions
Guinea pigs subjected to reduced oxygen tensions showed prompt rises in reticulated red cells which reached a peak (8-14%), in 7-12 days. Then the reticulocytes decreased and in 3-4 weeks approached the control level.
Intramuscular injection of liver extract prior to, simultaneously with, or following, exposure to reduced oxygen pressure, had no demonstrable effects on the reticulocyte response; and the bone marrow of liver-treated animals could not be distinguished from that of untreated controls.
Congo red was also without effect on the reticullocyte response of guinea pigs under reduced oxygen tensions.
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