Abstract
Conclusions
A cerebro-spinal meningitis due to a Type II pneumococcus has been produced in the rat. Oral treatment with sulfanilamide, instituted after this disease was well established, resulted in 73.3% cures; with 4,4'-di-(acetylamino)-diphenylsulfone, 40% cures, and with no treatment, 100% fatality. It is quite evident that the sulfone compound was not as effective against this pneumococcal strain as sulfanilamide.
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