Abstract
Summary
Splenectomy in rats is without effect on the ovarian and uterine weight response to injections of homozoic pituitary material. Splenectomized rats, however, show greater response when treated with pituitary material from a heterozoic source than similarly treated controls. This lends further support to the contention that the state of refractoriness which develops after prolonged treatment with hormone preparations is immunological in nature.
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