Abstract
Summary
Sulfanilamide was found to have a prophylactic value and a marked therapeutic effect on acute P. knowlesi infections in rhesus monkeys. It had, in addition, a direct action upon the parasites in vitro.
Sulfanilyl sulfanilate proved an ineffective prophylactic agent; it had no apparent in vitro action on the parasites, but some therapeutic value in acute P. knowlesi infection was noted.
In chronic infections 3.0 g of sulfanilamide given intraperitoneally was sufficient to render blood non-infectious for susceptible monkeys, while the same amount of sulfanilyl sulfanilate was without effect.
Sulfanilamide and sulfanilyl sulfanilate were ineffective for prophylaxis and had no therapeutic value when tested against infections produced by 2 different species of avian plasmodia.
Get full access to this article
View all access options for this article.