Abstract
The investigations of Luckhardt and Koppanyi 1 were concerned with the pressor effects of epinephrine hydrochloride injected sub-cutaneously and the effect of massage thereon. In the present work, two problems and their ramifications have been and are being studied. First, the absorption of epinephrine from injections in subcutaneous areas as compared with submucosal injections in the oral cavity. Secondly, the effect of subgingival injections of pro-caine-epinephrine hydrochloride solutions. Conclusions were drawn from a comparative measurement of the blood pressure changes as evidenced from these injections.
Dogs, 38 in number, were used in the series of experiments. An area on the chest wall was selected for the subcutaneous injections, whereas a site in the dog's mouth at the mucobuccal fold offered an easily accessible area for the submucosal injections. In some of the animals the subcutaneous injections were made prior to the sub-mucous injections, whereas on others the order of procedure was reversed to avoid any misinterpretation of results from the influence of previous epinephrine deposits.
Following submucosal injections, a rise in blood pressure ranging between 10-40 mm. of Hg. was noted. These rises were greater than those recorded from similar injections in the subcutaneous tissue, the greatest being 10 mm. of Hg. The time required for the blood pressure to return to a normal level was slightly greater following submucosal injections.
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