Abstract
Conclusions
Autopsy data correlated with observations on living animals have established the following points: (1) The testes of hypophysectomized parabiotic rats may be stimulated by hypo-physeal secretion from normal, cryptorchid, or castrated partners. (2) Gonadal stimulation in hypophysectomized test animals is greatest when they are joined with castrated partners and least when they are joined with normal partners. (3) Growth of the scrotum in hypophysectomized parabionts indicates interstitial cell activity, and increase in testicular size reflects predominantly spermatogenic activity. (4) Both these types of activity progress simultaneously under the influence of hypophyseal hormone from a partner, or regress simultaneously in the absence of adequate hormonal stimulation. (5) These results do not support the idea that the castrate hypophysis produces only, or chiefly, gametokinetic hormone, but are in agreement with our previous findings which indicated that the hypophyseal gonadokinetic hormone complex in castrate, crypt-orchid and normal parabiotic rats differed only in degree but not in type.
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