Abstract
Summary
1. In 15 monkeys and 8 humans testosterone propionate effected changes in specialized nasal areas. These changes produced by androgens occurred in both male and female monkeys. 2. In monkeys and in humans congestion, swelling and fluid formation were observed grossly. Histologically, perivascular edema was pronounced in the monkeys. 3. The nasal areas affected are similar to those which exhibit vicarious menstruation. Discussion is given as to possible physiological significance of gonad-controlled function of these areas with regard to warming of inspired air, the prevention of infection, and therapeutic use of gonadal substance in conditions of atrophic rhinitis and nasal hyposecretion.
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