Abstract
Summary and Conclusion
The anti-streptococcal effects of prontosil on oral administration are somewhat superior to those noted after subcutaneous injection. This confirms Rosenthal. 8 The chemotherapeutic efficiency of prontylin by the subcutaneous route is superior to that noted after oral medication. This confirms Proom 9 and Rosenthal. 8 The observed differences in efficiency by these 2 routes of administration were not due to the greater volume of fluid administered by the subcutaneous route, in that normal saline injections alone were of no therapeutic value. However, the superiority of the parcnteral route from a therapeutic standpoint is open to question, when due consideration is given to the low solubility of the compound and the close similarity between the time intervals, at which the peak! blood concentration occurs, after medication with equal dosages of prontylin by these 2. routes. (Marshall, et al. 12 )
Prontylin orally appears to be 1.8 times more effective than prontosil for low-grade infections and 1.4 times more effective for high-grade infections. The therapeutic margin of safety of prontosil administered orally, however, is quite superior to that of prontylin. Disulon orally in dosages of 40 gm. per kilo does not produce symptoms referable to the central nervous system. This compound, due to its lower toxicity, better tolerance and the greater protective efficiency of unit dosages in the presence of infections, has a therapeutic margin of safety quite superior to that of prontylin. The observed superior therapeutic efficiency of disulon as compared with prontylin confirms similar observations of Rosenthal. 10
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