Abstract
Summary
(1) Antiprolan has a paralyzing effect upon prolan in separate as well as in simultaneous injection in the test rat. Nevertheless, the inhibiting effect of antiprolan is stronger if we inject a prolan-antiprolan mixture which has been allowed to stand in the incubator for 2 hours. (2) The antigonadotropic effect can be observed 8 days after the application of antiprolan (100 PAU). During this period the test animal is refractory towards prolan (10 RU). (3) Antiprolan circulates in the blood of the test rat as long as 60 hours after subcutaneous injection. It cannot be proved in the organs of the rats at that time. (4) We are able to retard the gonadotropic effect of prolan in rats up to 24 hours after the injection, if we inject antiprolan within this interval. (5) If applied enterally antiprolan has no effect whatsoever.
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