Abstract
Summary
1. Normal rats receiving pituitary stimulation showed a slight positive thyroid response, as determined by differences in fresh weight, dry matter content, iodine content, and histological picture. 2. Rats with hyperplastic goiters, produced by an iodine-deficient diet, were just as resistant to pituitary stimulation as were the normals, 3. Iodine administration at a level which will just protect the normal rat against thyroid hyperplasia does not affect this resistance. 4. On the basis of the criteria used, the low-iodine hyperplastic goiter seems to differ from the reported spontaneous goiter, in that it does not alter the natural resistance of the rat to thyrotropic stimulation.
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