Hepatic Excretion in the Dog Following Oral Administration Various Bile Acids

Abstract

Summary

Oral administration of large amounts of the various bile acids to dogs with a common duct fistula indicate that, from the point of view of largest excretion of bile acids in most concentrated form, the natural bile acids of the dog were probably the most efficient. Under the conditions of these experiments pure ox bile salts and glycocholic acid were found to be more efficient than the unconjugated cholic and desoxycholic acids. The natural bile acids (cholic and desoxycholic acids, and their various conjugated forms) were more effective than dehydrocholic acid.