Abstract
Summary and Conclusions
The administration of pholorhizin results in a stimulationof the thyroid gland which in turn is responsible for part of the increased protein metabolism observed in pholrhizin diabetes. Since this increased protein metabolism of the phlorhizinized animal continues ever after the removal of the kidneys, but does not occur when phlorhizin is administreed to previously nephrectomized animals, 2 it is probable that this drug exerts some specific effect on the kidney, which is in turn responsible for the thyroid stimulation. Our observations do not offer evidence for the possibility that the blood sugar level is the responsible factor in the increased activity of the thyroid but suggest some primary renal factor.
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