Abstract
The results indicate that pancreatic tissue extract produces a lowering of the plasma cholesterol within one hour in cardiovascular arteriosclerosis. The cholesterol remains lowered, but with a tendency to return almost to former level in 24 hours. The effect is transitory, lasting about 21 hours. more or less. For sustained effect and progressive drop in plasma cholesterol, patients require doses at frequent intervals. When treatment is interrupted or dosage inadequate, the plasma cholesterol rises and there is an exacerbation of symptoms, precordial pain and intermittent claudication.
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