Oestrogenic Treatment of Hypophysectomized Male Mice. ∗

Abstract

Summary

In completely hypophysectomized male mice, treated with female hormone, the mammary gland rudiments do not respond. The gonads, accessories and adrenal cortex undergo regression regardless of the female hormone, present. The resorption of the pubic symphysis does not depend on the presence of anterior lobe material. A small fragment of prehypophysis enables the administered female hormone to induce growth of the mammary gland. Such a small pituitary fragment permits regression of the gonads, accessories and adrenal cortex. Caution must be urged in use of the term “physiologically hypophysectomized” anima1s.†